Top-Banner-plain

PLN-Associated Variant Genes Test Result Definitions

PLN-Associated Variant Genes Test Result Definitions - this table clarifies the reporting formats between PennGen and Laboklin:

 

Genetic term

Definition

What does this mean?

Other Common Terms

Test Results from Penn

Test Results from Laboklin

Homozygous Negative

A dog without any of the variant alleles

A dog that has no copies of the variant alleles is at the least risk of developing PLN

 

  •    0
  •    0/0
  •    No copies
  •    “Normal"
  •    “Clear”
  •     Homozygous

1/1

N/N (Clear)

Heterozygote

A dog with one copy of the variant alleles

A dog with one copy of the variant allele is at medium risk of developing PLN

 

  •    1
  •    0/1
  •    “Carrier”
  •    1 Copy
  •    Heterozygous

1/2

N/PLN

(Carrier)

Homozygous Positive

A dog with two copies of the variant alleles

A dog with two copies of the variant alleles is at the highest risk of developing PLN, but this does not mean it will develop PLN

  •    2
  •    Both copies
  •    Homozygous for the PLN causative mutation

2/2

PLN/PLN (Affected)

 

Affected refers to both copies of the allele, it does not mean this dog is currently or will be affected with PLN

  

© SCWTCA & San Jeffries

Genetic term

Definition

What does this mean?

Other Common Terms

Test Results from Penn Vet

Test Results from Laboklin

Homozygous Negative

A dog without any of the variant alleles

A dog that has no copies of the variant alleles is at the least risk of developing PLN

 

·   0

·   0/0

·   No copies

·   “Normal

·   “Clear”

·   Homozygous

1/1

N/N (Clear)

Heterozygote

A dog with one copy of the variant alleles

A dog with one copy of the variant allele is at medium risk of developing PLN

 

·   1

·   0/1

·   “Carrier”

·   1 Copy

·   Heterozygous

1/2

N/PLN

Homozygous Positive

A dog with two copies of the variant alleles

A dog with two copies of the variant alleles is at the highest risk of developing PLN, but this does not mean it will develop PLN

·   2

·   Both copies

·   Homozygous for the PLN causative mutation

2/2

PLN/PLN (Affected)

 

Affected refers to both copies of the allele, it does not mean this dog is currently or will be affected with P